05 Dec 2020

propofol dosage chart

Propofol Dosage and Administration. For constant infusion, propofol is dosed at 0.05 to 0.3 mg per pound per minute (0.1 to 0.6 mg/kg/min). There is a lack of intensive care unit (ICU) studies assessing the accumulation of propofol in obese patients that are mechanically ventilated receiving long-term sedation. Undesirable effects such as cardiorespiratory depression are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in the infusion rate. The answer is 24 mL/hr. Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min. The last American College of Emergency Physicians (ACEP) guideline recommendations regarding the use of propofol for ED procedural sedation was in 2007. The dose and rate for propofol … 240 mg become the dose ordered, 10 mg is the dose available, 1 mL is the volume available. Maintenance Dosage Guidelines Preanesthetic* Propofol Maintenance Dose Propofol Rate of Administration mg/kg Seconds mg/kg/ min mL/kg/ min None 3.2 60 3.2 0.32 Benzodiazepine/ Opioid 1.7 60 1.7 0.17 Phenothiazine/ Opioid 2.0 60 2.0 0.20 *Doses for preanesthetics may be lower than the label directions for their use as a single medication2. Dosing Information of Propofol for Dogs and Cats; Propofol is dosed at 1.5 to 4 mg per pound (3 to 8 mg/kg) intravenous, given slowly over 1 minute. Methods. Pre=treatment–’agentsshouldbe’given3minutespriortointubation ’(canbe’ giveninanyorder)’ Drug’ Dose’ Indication’ Other’notes’ Propofol is chemically described as 2,6-diisopropylphenol. This table is based on field study results and is for guidance only. Background: Propofol is a lipophilic medication shown in pharmacokinetic studies to accumulate over time and potentially cause over sedation in obese patients when dosing is based on total body weight. Propofol is slightly soluble in water and, thus, is formulated in a white, oil-in-water The median duration of the propofol maintenance infusion was … Propofol blood concentrations at steady-state are generally proportional to infusion rates, especially in individual patients. A brief description of propofol … The average PropoFlo™ 28 induction dose rates for healthy dogs given propofol alone, or when propofol is preceded by a preanesthetic, are indicated in the table below. Furthermore, many clinicians are co-administering ketamine or fentanyl in conjunction. Much research has since demonstrated its safety in adults and children. Propofol (10 mg/mL) (1 - 8 mg/kg) Robenacoxib (20 mg/mL) (2 mg/kg) Tiletamine/ zolazepam (100 mg/mL) (1 - 4 mg/kg) EQUIPMENT AND SUPPLIES: Breathing Circuit. Anesthesia was induced with a median propofol dose of 1.4 mg/kg (range: 0.9 to 6.9 mg/kg) and maintained with a median maintenance propofol dose of 146 mcg/kg/min (range: 68 to 425 mcg/kg/min). 100 to 150 mcg/kg/min (primary propofol) 50 to 100 mcg/kg/min (secondary propofol). It is the responsibility of the providing veterinarian to decide drug dosages for an … 178.27 . (propofol) injectable emulsion, USP is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. The aim of the study was to develop propofol dosing guidelines for ICU sedation based on an integrated pharmacokinetic-pharmacodynamic model of propofol infusions in ICU patients. The structural formula is: C 12 H 18 O M.W. Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg). Maximum dose of 15,000 mcg/min. Propofol is available in 10mg/ml concentration in 20 ml, 50 ml and 100 ml bottles. 240/10 x 1 = 24. 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